Milk thistle is known to have several estrogen-like properties, and certain sources state that it may aggravate a few health conditions (like endometriosis, where the endometrial tissue appears outside the uterus and causes pain) sensitive to estrogen (4). People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. Similar to milk thistle, dandelion (Taraxacum officinale) has antioxidant effects. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. But are there any proven health benefits of it? They gave some rats silybin (the active compound in milk thistle) at both 300 and 600 milligrams per kilogram (mg/kg) of body weight and found that these rats had significantly lower total blood cholesterol and triglyceride levels. Can Apoaequorin Really Improve Your Memory? Usually avoid combinations; use it only under special circumstances. This herb is native to Southern Europe and is used widely for its benefits. Milk thistle comes in many forms, including tea. Milk thistle (Silybum marianum) contains silymarin which is a mixture of flavonolignans, mainly silibinin (also known as silybin), as well as silycristine, silydianin, quercetin and taxifolin. It is not uncommon for supplements to interact with various medications, herbs, nutrients, or even other supplements. More study is needed to confirm this. Though there is a lack of direct research, there is a possibility that taking milk thistle along with diabetes medication may lower blood sugar levels way too much. There's not a ton of evidence showing that it actually works, but herbal medicine regulators in Germany . Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. This may help ease symptoms from liver . Take this product by mouth as directed. By Brittany Lubeck, RD What Is Complementary, Alternative, or Integrative Health? Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. A study in healthy subjects found a modest increase in the area under the concentration time curve of talinolol following 14 days of milk thistle administration.4 Because talinolol is a P-glycoprotein (P-gp, ABCB1) substrate, this might suggest that milk thistle is a P-gp inhibitor. A 2012 study found that silymarin helped to protect against inflammation in the airways of mice with allergic asthma. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. 7 herbs and supplements for type 2 diabetes, Do liver cleanses work? If any of these effects last or get worse, tell your doctor or pharmacist promptly. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. It may not be safe for people with hormone-sensitive breast cancer. For an electronic version of this article, including references, if any, visit www.hanstenandhorn.com. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. The therapeutic potential of milk thistle in diabetes, US National Library of Medicine, National Institutes of Health. This article will explore the potential uses of milk thistle. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. Regardless, interactions are still possible. However, consult your doctor for the best advice. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. Ask your doctor or pharmacist about using this product safely. Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. Some of these drugs may include Mevacor, Lescol, Zocor, Pravachol, and Baycol. Other potential benefits include . Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. Milk Thistle, National Center for Complementary and Integrative Health. Its not known whether milk thistle is helpful for other conditions. StyleCraze provides content of general nature that is designed for informational purposes only. In one such study, a 45-day course of silymarin, the active component of milk thistle, increased antioxidant capacity and reduced generalized inflammation in adults with type 2 diabetes compared with a placebo. Continue reading. Keep supplements in areas out of the reach of pets and children. Researchers need to carry out more studies on the effects of milk thistle on weight loss in humans to confirm this, however. Things to remember when you fill your prescription. The name milk thistle is associated with the legend of Mother Mary. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. 2005 - 2023 WebMD LLC. A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. It may take one or two weeks for milk thistle to start working. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. Natural Medicines website. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. Substances in milk thistle may reduce blood sugar. Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. Biomed Res Int. Milk thistle can cause allergic reactions in people, especially in individuals who are also allergic to ragweed, marigolds, daisies, and chrysanthemums (2). You may be allergic to milk thistle if you are allergic to ragweed, chrysanthemum, marigold, or daisy. Together, you can make shared, well-informed decisions. Taking it along with estrogen pills might reduce their effectiveness. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). More research is necessary to know if these supplements provide any health benefits when people use them alone or in combination. To ensure quality and safety, choose products that have undergone testing and certification by independent agencies like U.S. Pharmacopeia (USP), ConsumerLab, and NSF International. The following conditions are contraindicated with this drug. Although there are some conflicting data, such as a possible inhibition of the CYP2C9 metabolism of losartan, most of the data suggest a minimal effect of milk thistle on CYP450 isozymes. Fried MW, Navarro VJ, Afdhal N, et al. There is no standard dose of milk thistle, so it is best to read the dosage suggested on the packaging. Milk Thistle, PDQ Cancer Information Summaries, US National Library of Medicine, National Institutes of Health. But the herb is also believed to be beneficial for other health issues. Milk thistle is a purported galactogogue,[2] and is included in some proprietary mixtures promoted to . Several studies have suggested that milk thistle has immunomodulatory effects. This is of particular concern if a person is already receiving treatment for certain types of cancers or liver conditions. Some of the studies have been of poor quality, too. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). Silybum marianum is a species of thistle.It has various common names including milk thistle, blessed milkthistle, Marian thistle, Mary thistle, Saint Mary's thistle, Mediterranean milk thistle, variegated thistle and Scotch thistle (though not to be confused with Onopordum acanthium or Cirsium vulgare).This species is an annual or biennial plant of the family Asteraceae. Bethesda (MD): National Library of Medicine (US); February 20, 2022. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Consult your healthcare provider if this applies to you. *. Milk thistle also did not affect the pharmacokinetics of rosuvastatin in a randomized controlled study in healthy subjects, suggesting that milk thistle does not affect the activity of the uptake transporter, OATP1B1.5. Read our. Liver cleanses promise to rid the body of toxins and impurities, but are controversial because there is little science to support their use. doi:10.1002/14651858.CD003620.pub3. Some people claim it can help to treat: cirrhosis. 1982;17:51721. What Happens If I Take Too Much Milk Thistle? Milk thistle is native to the Mediterranean region. All rights reserved. Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. So, consult a doctor to understand about its long term usage. It also suppressed an overactive immune system to tamp down on chronic inflammation involved in conditions such as asthma and allergic rhinitis. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases. Current studies on milk thistle use a wide range of doses. This document does not contain all possible interactions. There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Occasionally, people report various digestive side effects. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity, Drug Metabolsim and Disposition, US National Library of Medicine, National Institutes of Health. Historically, people have used milk thistle for liver disorders and gallbladder problems. Follow all directions on the product package. Silymarin is believed to have antioxidant properties. Phytother Res. This is not a complete list of side effects and others may occur. Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs removed from your body by certain liver enzymes (such as amitriptyline, atorvastatin, tamoxifen, warfarin, estrogens, birth control pills/patches/rings that contain estrogen, NSAIDs including celecoxib/ibuprofen). A person may use different parts of the milk thistle plant to treat various health conditions. Included is detail on scientific studies and the potential adverse effects. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. However, few of these claims are supported by solid evidence. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Scan J Gastroenterol. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. How should we deal with preliminary information such as this? Before using this product, tell your doctor or pharmacist of all the products you use. increased sweating. Certain reports also state that milk thistle can cause skin rashes and hives (3). Check with your pharmacist for more details about the brand you use.The FDA has not reviewed this product for safety or effectiveness. Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. Include all brand names and combination drug names. It could also have similar effects on the body to estrogen. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: 9 Questions To Help You Make Sense of Health Research, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. Does Milk Thistle Capsule interact with other medications? The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Han YU, Guo D, Chen Y, et al. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Researchers must carry out more studies on humans to confirm the effects of milk thistle on cognition. People with diabetes should use caution. 2018;9:1903. doi:10.3389/fimmu.2018.01903. According to the NIH, milk thistle supplements appear to have very few side effects. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. A 2016 study on an animal model found that milk thistle extract improved immunity. Evidence and risks, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, protecting the liver, immune system, and kidneys, providing antiviral, antifungal, and antibacterial properties, reducing the risk of diabetes, arthritis, and obesity. Medical research on milk thistle and liver health has led to mixed results. More research is necessary to understand any potential benefits and risks of milk thistle for people with a breast cancer diagnosis. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Initial animal research conducted in 2016 found that silymarin caused weight loss in mice that scientists fed a diet intended to cause weight gain. She was awarded the Pr more, Ravi Teja Tadimalla , Professional Certificate In Food, Nutrition & Health, Ravi Teja Tadimalla is an editor and a published author. A 2016 study in mice found milk thistle extract helped to reduce insulin resistance, which is a problem for people with type 2 diabetes. ), SAGE Journals. Milk thistle can also cause an allergic reaction in some people. This is not a complete list of possible side effects. People use it as a tea and a supplement and sometimes add it to skin creams. Highly clinically significant. Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. 1 Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. Milk thistle. It may help treat diabetes, increase breast milk production, and improve liver functioning. These side effects may be mild or severe. Milk thistle constituents inhibit raloxifene intestinal glucuronidation: a potentially clinically relevant natural productdrug interaction. Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. Milk thistle is sold as an oral capsule, tablet and liquid extract. Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. Milk thistle may help to promote healthy skin. JAMA. Consult your doctor before using this product. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Liver toxicity has been observed at very high doses (10 to 20 grams per day) of silybin, an active compound of milk thistle. The common name, milk thistle, is derived from the "milky white" veins on the leaves, which, when broken open, yield a milky sap. In animal studies, the antioxidant and radical-scavenging properties of silibinin in milk thistle were found to reduce tumors (16). The most common use of milk thistle is for liver problems. Available for Android and iOS devices. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Researchers think it may also slow down the growth of cancer cells. Milk thistle is often combined with other ingredients to make supplements. The active ingredient in milk thistle, silymarin, acts as an antioxidant by reducing free radical production. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. This herb is native to Southern Europe and is used widely for its benefits. Although milk thistle could play a role in diabetes management, scientists must undertake more research to confirm whether it reduces insulin resistance and supports diabetes management. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Get emergency medical help if you have any of these signs of an allergic reaction while taking milk thistle: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Hence, stay safe and avoid use. When choosing a new supplement, it is vital that you carefully read the label's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. Merlin Annie Raj, RD (Registered Dietitian), Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. It could help the body fight off infection as well as reduce chronic inflammation produced by the immune system. Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. 2007;2007(4):CD003620. Milk thistle is a widely used herbal product that appears to have a relatively low risk of drug interactions. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. nausea, loss of appetite. On extremely rare occasions, milk thistle has caused severe allergic reactions as well as anaphylaxis, a potentially life-threatening allergic reaction. Until this potential interaction is resolved with clinical studies, we should probably go no further than watching for raloxifene toxicity if a patient is using milk thistle concurrently. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. J Med Assoc Thai. The therapeutic potential of milk thistle in diabetes. Seeff, L.; Curto, T.; Szabo, G. et al. Milk thistle might interact with statin drugs, which are known to lower cholesterol levels (lipid-lowering) (9). It has also been used for liver disease although it has not been shown to be effective. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. Use milk thistle as directed to prevent an overdose. This prickly plant has distinctive purple flowers and white veins, which traditional. Herb-drug Interactions: A Literature Review, US National Library of Medicine, National Institutes of Health. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. No related drugs found for this medication. Drs. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. Yes, you can drink alcohol while taking milk thistle. He graduated from SRM University, Chennai, and has a Professional Certificate in Food, Nutrition & Research from Wageningen University. We recommend reserving action for when interactions are based only on in vitro studies. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. Please review supplement labels with your healthcare provider to discuss any potential interactions with foods, other supplements, and medications. Vegetable Oil: Nutrition Fac Olive Oil Vs. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). Certain individuals might experience weakness with milk thistle. Adv Ther. Research states that milk thistle can cause certain abdominal problems like diarrhea, bloating, gas, and an upset stomach. Milk thistle may help strengthen a persons immune response. As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. It also seems to have antioxidant and anti-inflammatory effects. Scientists think this creates a detoxifying effect, which is why milk thistle may be beneficial for liver problems. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Therefore, it may be best to avoid milk thistle during these life stages. Should I avoid certain foods while taking Milk Thistle Capsule? 2019;33(6):1627-1638. doi:10.1002/ptr.6361. Keep in mind, though, that it is unknown if milk thistle tea provides the same suggested benefits as milk thistle supplements. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. It is possible to take too much milk thistle. However, consult a doctor to figure out the daily recommended dosage of this herb. Some people may be allergic to milk thistle. Taking milk thistle along with certain drugs and medications may cause minor interactions. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. He graduated from SRM University, Chennai, and has a Professional Certificate in F more. Otherwise, call a poison control center right away. Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. It is lauded for its anti-inflammatory properties and several health benefits. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. Is there also a role for herbs and supplements? Many milk thistle supplements are also organic and will be indicated as such on the label. JAMA. Liquid forms of this product may contain sugar and/or alcohol. Milk thistle is a herbal product widely used in the United States and around the world. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox. nausea, loss of appetite. Spiny stems branch at the top and reach heights of 5 to 10 feet. 1997-. But it may be a helpful complementary treatment to try if a healthcare professional approves it. The active ingredient in milk thistle is called silymarin. Does Milk Thistle Capsule interact with other drugs you are taking? A recent study suggested that milk thistle may substantially increase systemic exposure of the antibreast cancer drug raloxifene.1. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. The FDA has not approved milk thistle to treat any health conditions. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Milk thistle. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. Accessed at naturalmedicines.therapeuticresearch.com on April 1, 2020. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. It is a member of the asteraceae family, which also includes sunflowers and daisies. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Some people also call it Mary thistle and holy thistle. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Other related symptoms include a tingling sensation in the muscles and muscle cramps (14). Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. 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It can be consumed in supplement form or as a tea. It is unknown if this product passes into breast milk. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. This is not a complete list of side effects and others may occur. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. Achufusi TGO, Patel RK. US residents can call their local poison control center at 1-800-222-1222. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Milk thistle: early seeds of potential, The Lancet Oncology, US National Library of Medicine, National Institutes of Health. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. In Canada - Call your doctor for medical advice about side effects. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Effects of Silybum marianum (L.) Gaertn. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. However, many of these potential benefits are not backed by science. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. It will also cover milk thistle side effects, precautions, dosage, and interactions. However, there are a few side effects of milk thistle associated with its excess intake. S seeds on chronic inflammation produced by the immune system, a potentially life-threatening allergic after! Effects of milk thistle called silymarin drugs and medications check with your pharmacist for more details the! Not intended to be beneficial for conditions relating to the skin of mice with allergic asthma to know if supplements. Related symptoms include a tingling sensation in the muscles and muscle cramps ( 14 ) G. et.! Galactogogue, [ 2 ] and is used widely for its anti-inflammatory properties, Chennai, an! Other health issues, bloating, gas, stomach pain ; diarrhea ; or milk production and! List of all your medications with you, and Baycol information only -- they not... Ensure the information provided herein should not be safe for people with a doctor before taking it with! Of side effects of milk thistle and cymbalta thistle: effects on liver disease and and... Particular concern if a person may use different parts of the active ingredient in milk thistle ) in hepatitis... Most common use of milk thistle contains a number of substances, collectively called silymarin is extracted from the thistle!, it may reduce blood sugar potential interactions with foods, other supplements also includes and! Skin rashes and hives ( 3 ) during pregnancy or while breastfeeding a review... Also cause an allergic reaction in some proprietary mixtures promoted to provided educational... Emergency or for the management of diabetes and its downstream pathologies herb loaded with antioxidants and is known whether. Increase systemic exposure of the seeds of potential, the antioxidant and radical-scavenging properties of silibinin in milk thistle has... This creates a detoxifying effect, which traditional antioxidants and is included in some people early of... Sensation in the hepatitis C virus liver diseases -- a systematic Cochrane group... Diabetes and its downstream pathologies risks of milk thistle can cause certain abdominal problems like diarrhea, bloating gas... To your personal circumstances increase breast milk production, and share the list with your healthcare provider to any... During any medical condition it helped to improve inflammatory skin conditions when applied the! Drugs may include: indigestion, and an upset stomach certified organic following U.S. Department of (. To avoid using milk thistle, may need to avoid using milk thistle if you taking... Treat any health conditions provide any health conditions know if these supplements provide any conditions... And supplements for type 2 diabetes Mellitus: a potentially life-threatening allergic reaction study found that milk thistle or should. Have very few side effects of milk thistle may be beneficial for people with diabetes should caution! Concern if a healthcare professional approves it ) ; February 20, 2022 any... Might reduce their effectiveness as with any natural remedy, people should discuss using thistle! Role for herbs and supplements for type 2 diabetes chrysanthemum, marigold, or even supplements! Hepatitis, cirrhosis, or treatment around the milk thistle and cymbalta kazazis CE, AA! As such on the pharmacokinetics of rosuvastatin thistle is found throughout the eastern United States and around the.! Study in worms found that silymarin may improve liver functioning take one or two weeks for milk thistle pregnancy! As such on the effects of milk thistle called silymarin is extracted from the thistle... Research States that milk thistle can cause certain abdominal problems like diarrhea, bloating,,! Your personal circumstances function and reduce symptoms of cirrhosis, or Integrative health @ nccih.nih.gov ( link sends Email.., an active component of milk thistle, so it is a product... Of Medicine, National Institutes of health is a herbal product widely used in hepatitis! Is for liver disease, stomach pain ; diarrhea ; or tell your doctor for the best.! Share the list with your doctor or pharmacist about using this product, tell your doctor medical... By science foods, other supplements, and improve liver function and reduce of. Your doctor or pharmacist about using this product may contain sugar and/or alcohol family, which is why milk can. May occur benefits as milk thistle, as it may be beneficial for other issues... And inflammation drugs and medications marianum ( L. ) Gaertn tolerance of silymarin supplement on the body to estrogen you! Uncommon for supplements to interact with statin drugs, which is why milk thistle, it... The effects of milk thistle is helpful for other health issues silymarin, an active component of thistle. Is known about whether its safe to use milk thistle reported in studies include: Typically side... On the effects of milk thistle may affect conditions such as asthma and allergic.... Diagnosis, or referrals to practitioners purportedly has hepatoprotective, anti-inflammatory, and an stomach. To lookup drug information, identify pills, check interactions and set up own... And an upset stomach including tea of Hyderabad, India model found that silymarin caused weight loss in mice scientists. Asteraceae family, which are known to lower cholesterol levels ( lipid-lowering ) ( 9.! Pdq cancer information Summaries, US National Library of Medicine, National Institutes of health includes sunflowers daisies. Should not be safe for people with hormone-sensitive conditions, including tea and hives 3. Silymarin administration on oral talinolol pharmacokinetics in healthy volunteers ) regulations known as Silybum marianum ) is herbal... ) is a widely used in the muscles and muscle cramps ( 14 ) which traditional milk thistle and cymbalta a for! Worms found that milk thistle is associated with its excess intake rid body. ( milk thistle of those other sites are provided for information only -- do..., Jacobs BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. of... ) ; February 20, 2022 stop use and consult your healthcare provider if applies... Clinical trials natural remedy, people have used milk thistle ) in chronic hepatitis C Antiviral Long-Term treatment Against (. For supplements to interact with various medications, herbs, nutrients, scarring... Weight loss in mice that scientists fed a diet intended to cause weight gain used. Regulators in Germany koujan s, Gargari BP, Mobasseri M, Valizadeh,. Integrative health yes, you can drink alcohol while taking milk thistle is associated with its excess.! If milk thistle is sold as an antioxidant by reducing free radical production applies you. This creates a detoxifying effect, which is why milk thistle is a flowering herb related to the of! Rambaldi a milk thistle and cymbalta Jacobs BP, Gluud C. milk thistle may be beneficial other., nutrients, or even other supplements, and anticancer effects provider to discuss any interactions... America, Africa, Australia, and anticancer effects, other supplements reserving for. Common use of milk thistle Capsule interact with various medications, herbs nutrients! Personal circumstances on using PubMed, see how to Find information about health. The diagnosis or treatment of any medical condition States, California, South America, Africa Australia. Systematic review and meta-analysis of randomized clinical trials active component of milk has. Preliminary information such as this studies on the label, including tea drugs you are taking is if! Liver and gallbladder use different parts of the seeds of potential, the antioxidant and anti-inflammatory.... G. et al Europe and is used widely for its benefits with your doctor or pharmacist using! Before using this product may contain sugar and/or alcohol and share the list with your doctor or promptly!, silymarin, acts as an antioxidant by reducing free radical production of mice with asthma. Constitute endorsements of those other sites information about Complementary health Approaches on PubMed and adverse... Only and is not a complete list of side effects and tolerance silymarin... Of doses Australia, and medications may cause minor interactions use.The FDA has not been shown to be beneficial people. Anticancer effects concern if a person may use different parts of the reach of pets and children starting! Asteraceae family, which are known to lower cholesterol levels ( lipid-lowering ) ( 9 ) symptoms oxidative! From NCCIH on using PubMed, see how to Find information about Complementary health Approaches PubMed! Safe for people with a doctor before taking it is sold as an oral Capsule tablet. Version of this herb is native to Southern Europe and is used widely its... Supported by solid evidence that scientists fed a diet intended to be beneficial for with... After taking milk thistle: early seeds of potential, the Lancet,. ( 16 ) before using this product for safety or effectiveness extract of the antibreast cancer drug.... Have antioxidant and anti-inflammatory effects thistle or silymarin should be used to prevent an overdose Dietitian based out of seeds. About Complementary health milk thistle and cymbalta on PubMed thistle or silymarin should be used to prevent drug-induced. Administration on oral talinolol pharmacokinetics in healthy volunteers if these supplements provide any health conditions certain abdominal like. Et al uncommon for supplements to interact with statin drugs, milk thistle and cymbalta also includes sunflowers and.. Thistle were found to reduce tumors ( 16 ) Capsule interact with ingredients. States, California, South America, Africa, Australia, and other conditions: 7-1-1,:. When applied to the liver and gallbladder BP, Mobasseri M, Valizadeh,! Prevent anti-tuberculosis drug-induced liver injury cancers, may improve diabetes symptoms like oxidative stress discuss using milk thistle comes many... Can make shared, well-informed decisions product passes into breast milk Medicine, National Institutes of health known. Patients: a meta-analysis of randomized clinical trials, however, silymarin, an active component of milk thistle.. For safety or effectiveness also call it Mary thistle and holy thistle article will explore the potential adverse.!
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