Alzheimer disease: amyloidogenesis, the presenilins and animal models. The concentration of miRNA-132 is also reduced in the brains of patients with Alzheimer's disease. Despite many years of intensive research our understanding of the molecular events leading to this pathology is far from complete. -, Bai Q., Burton E. A. Zebrafish possess genes orthologous to those mutated in familial Alzheimer's disease and research using zebrafish has revealed unique characteristics of these genes that have been difficult to observe in rodent models. Work in zebrafish has permitted discovery of unique characteristics of these genes that would have been difficult to observe with other models. Moussavi Nik SH, Newman M, Wilson L, Ebrahimie E, Wells S, Musgrave I, Verdile G, Martins RN, Lardelli M. Hum Mol Genet. Abramsson A., Kettunen P., Banote R. K., Lott E., Li M., Arner A., et al. THE FUTURE FOR MODELING ALZHEIMER’S DISEASE IN ZEBRAFISH. Alzheimer's disease ... the research team performed a simple experiment using a zebrafish model and separated two genes that pair up ... "If this were a human the person would have no disease. | Clipboard, Search History, and several other advanced features are temporarily unavailable. In addition, the genetic material of these fish is easy to manipulate, meaning that they are often used as a model in the study of all sorts of diseases. ► Zebrafish embryos are a powerful tool for molecular biological analyses of Alzheimer's disease molecular pathology. ► Zebrafish possess orthologues of human genes involved in familial and sporadic Alzheimer's disease. eCollection 2018. Novel transgenic zebrafish models expressing wild-type or mutant forms of human 4R-tau in neurons have recently been reported. In this brief review we give an overview of Alzheimer's disease and transgenic animal models before examining the current contribution of zebrafish to this research area. -, Arslanova D., Yang T., Xu X. Y., Wong S. T., Augelli-Szafran C. E., Xia W. M. (2010). Abidar S, Boiangiu RS, Dumitru G, Todirascu-Ciornea E, Amakran A, Cioanca O, Hritcu L, Nhiri M. Antioxidants (Basel). PLoS One. Proc. Would you like email updates of new search results? 2015 Jul 1;24(13):3662-78. doi: 10.1093/hmg/ddv110. Biochim Biophys Acta. Some would even argue that the latest triple TG mouse (app/ps1/tau) is not a good enough model for AD. -. USA.gov. As the population ages, there is a growing need for effective therapies for the treatment of neurological diseases. COVID-19 is an emerging, rapidly evolving situation. Zebrafish start reproducing after only 3 months. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, https://doi.org/10.1016/j.bbadis.2010.09.012. Biol. Zebrafish are being widely used as a predominant model for studying neurodegenerative diseases. The control group was maintained in the medium with 0.2% DMSO. Recently it has become apparent that these powerful methodologies might be deployed in order to elucidate the pathogenesis of human neurodegenerative diseases … -, Babin P. J., Thisse C., Durliat M., Andre M., Akimenko M. A., Thisse B. The main genes involved in human AD have homologous counterparts in zebrafish and have conserved function. However, there are still aspects of this model that require better understanding. No effective treatments have been defined and questions surround the validity and utility of existing animal models. 2007 Mar;1772(3):285-97. doi: 10.1016/j.bbadis.2006.12.001. The zebrafish is becoming an increasingly popular model for the investigation of Alzheimer's disease and will complement studies using other models to help complete our understanding of this disease. Please enable it to take advantage of the complete set of features! Zebrafish larvae were divided into several groups: control group, model group, model + DPZ group, model + compounds groups, each of which contained 30 larvae. In this current study, we have attempted to establish Aβ induced model of AD in Zebrafish. The zebrafish animal model is emerging as a valuable model for the investigation of AD and neurodegenerative drug discovery. (2011). Alzheimer's disease is the most prevalent form of neurodegenerative disease. 381 377–388 10.1016/j.ydbio.2013.06.026 U.S.A. 94 8622–8627 10.1073/pnas.94.16.8622 Despite many years of intensive research using these models we still lack a detailed understanding of the molecular events that lead to neurodegeneration. Zebrafish possess orthologues of human genes involved in familial and sporadic Alzheimer's disease. The genetic code of humans and zebrafish is more than 90 % identical. Adv Sci (Weinh). 2020 Mar 13;8:116. doi: 10.3389/fcell.2020.00116. 10:24 10.1186/1472-6750-10-24 The zebrafish amyloid precursor protein-b is required for motor neuron guidance and synapse formation. We have created the world’s first zebrafish models of mutations that, in humans, cause inherited, early onset forms of Alzheimer’s disease. 2018 Oct 25;13(10):e0206155. This site needs JavaScript to work properly. Zebrafish possess genes orthologous to those mutated in familial Alzheimer’s disease and research using zebrafish has revealed unique characteristics of these genes that have been difficult to observe in rodent models. Zebrafish are increasingly used as a model for neurotoxic effects because the neuropathological behavior is relatable to that shown in humans. Alzheimer disease; MAPT; amyloid beta-protein precursor; gamma-secretase; presenilins; zebrafish. | See this image and copyright information in PMC. The zebrafish is rapidly emerging as an attractive model for AD research. The Diverse Roles of Phagocytes During Bacterial and Fungal Infections and Sterile Inflammation: Lessons From Zebrafish. Uncontrolled movements are typical in human patients with Parkinson’s. The molecular pathology of Alzheimer's disease is still poorly understood. Natl. Several AD models using zebrafish have been created but none of them are able to recreate both molecular and behavioral hallmarks of AD [2]. Generation of a transgenic zebrafish model of Tauopathy using a novel promoter element derived from the zebrafish eno2 gene. A., Hukriede N. A., Burton E. A. Zebrafish genes orthologous to those mutated in human familial Alzheimer's disease have been defined. Zebrafish have been used extensively in developmental biology and molecular genetics. Dev. They are an ideal model for drug testing prior to clinical testing in rodents. Persistent physiological stresses can induce abnormalities in heart functions such as cardiac hypertrophy (CH), which can lead to morbidity and mortality. In this review we give an overview of how the zebrafish has been used to study Alzheimer's disease. Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development. Zebrafish is an elegant vertebrate employed to model the pathological etiologies of human maladies such as cardiac diseases. This article is part of a Special Issue entitled Zebrafish Models of Neurological Diseases. eCollection 2020 Sep. Özcan GG, Lim S, Leighton P, Allison WT, Rihel J. Elife. NLM One way to test this is to look at their behaviour. The amyloid-β protein (Aβ)-containing neuritic plaques and hyperphosphorylated tau-containing neurofibrillary tangles are two invariable characteristics of Alzheimer's disease (AD). Javed I, Zhang Z, Adamcik J, Andrikopoulos N, Li Y, Otzen DE, Lin S, Mezzenga R, Davis TP, Ding F, Ke PC. Acad. Cadmium and aluminum are neurotoxins (2013). Zebrafish embryos are a powerful tool for molecular biological analyses of Alzheimer's disease molecular pathology. Epub 2006 Dec 8. Alzheimer’s disease. Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity. | Skeletal muscle makes up a considerable portion of the zebrafish trunk and has an exceptionally high degree of similarity to human muscle both molecularly and histologically. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. In the present study, [...] Zebrafish possess 70% similarity with the human genome. These studies show disease-relevant changes including tau hyperphosphorylation, aggregation and somato-dendritic relocalization. Exploring Alzheimer's disease in zebrafish. 2020 Apr 8;9(4):304. doi: 10.3390/antiox9040304. Zebrafish models of tauopathy. The emerging use of the zebrafish model in neurological and neurodegenerative human diseases (such as PD, autism, Huntington’s disease, and Alzheimer’s disease) was described by Xi et al. The zebrafish orthologue of familial Alzheimer's disease gene PRESENILIN 2 is required for normal adult melanotic skin pigmentation. J Alzheimers Dis. In Alzheimer's disease (AD), the microtubule‐associated ... of human tau expressed in zebrafish neurons produced a cytoskeletal disruption that closely resembled the NFT in human disease. BMC Biotechnol. Zebrafish is rapidly emerging as a promising model organism to study various central nervous system (CNS) disorders, including Alzheimer's disease (AD). Transgenic zebrafish model of neurodegeneration. NIH But do our zebrafish models suffer from dementia like humans? Acta 1812 353–363 10.1016/j.bbadis.2010.09.004 Sleep is bi-directionally modified by amyloid beta oligomers. Copyright © 2021 Elsevier B.V. or its licensors or contributors. In this review we give an overview of how the zebrafish has been used to study Alzheimer’s disease. 2020 Jul 14;9:e53995. By continuing you agree to the use of cookies. At the Copyright © 2010 Elsevier B.V. All rights reserved. 2010;20(4):981-90. doi: 10.3233/JAD-2010-1412. In a fish model of amyloid accumulation (a hallmark of Alzheimer's disease), only some of these populations increased proliferation to restore lost cells. HHS doi: 10.1371/journal.pone.0206155. Epub 2015 Mar 26. Alzheimer’s disease (AD) entails versatile pathological changes such as synaptic degeneration, neuronal death, chronic inflammation, impaired vasculature function, and reduced plasticity of neural stem cells (NSCs) [1–3].The cognitive decline that is observed in AD patients and experimental animal models is mainly caused by the reduced neural network … Newman M, Verdile G, Martins RN, Lardelli M. Biochim Biophys Acta. Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC. doi: 10.7554/eLife.53995. 35 6501–6516 10.1093/nar/gkm608 We will see that the fish in this study seem to show similar behavior. ► The molecular pathology of Alzheimer's disease is still poorly understood. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Zebrafish as a tool in Alzheimer's disease research. eCollection 2020. Zebrafish as a tool in Alzheimer's disease research. -, Bai Q., Garver J. This article is part of a Special Issue entitled Zebrafish Models of Neurological Diseases. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. To fill this need, we have been exploring the use of the protein phosphatase 1 (PP1) and 2A (PP2A) inhibitor, okadaic acid (OKA) [3], to induce AD-like pathology in zebrafish. The basic brain structure of the zebrafish is also conserved when compared to the mammalian brain. Deconstructing Neurogenesis, Transplantation and Genome-Editing as Neural Repair Strategies in Brain Disease. Epub 2010 Oct 12. Title:Generation of Alzheimer’s Disease Transgenic Zebrafish Expressing Human APP Mutation Under Control of Zebrafish appb Promotor VOLUME: 14 ISSUE: 6 Author(s):Yun-Zhu Pu, Liang Liang, Ai-Ling Fu, Yan Liu, Lan Sun, Qian Li, Dan Wu, Man-Ji Sun, Ying-Ge Zhang* and Bao-Quan Zhao* Affiliation:State Key Laboratory of Toxicology and Medical Countermeasures, Institute of … 2020 Jun 5;11:1094. doi: 10.3389/fimmu.2020.01094. Front Cell Dev Biol. (2007). (1997). Introduction. The zebrafish (and, in particular, its embryos) is a malleable and accessible model possessing a vertebrate neural structure and genome. The first gene implicated with PD was SNCA that encodes to alpha-synuclein. The present invention further … Biophys. 2020 Jul 16;7(18):2001299. doi: 10.1002/advs.202001299. Zebrafish possess genes orthologous to those mutated in familial Alzheimer's disease and research using zebrafish has revealed unique characteristics of these genes that have been difficult to observe in rodent models. Querying for a disease name retrieves results linking to the disease pages, including zebrafish models for this disease, as well as a list of genes involved in the disease, which is based on orthology with human genes and publications related to the disease (Figure 5A). 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Plays ancient, conserved roles in suppression of the zebrafish has been used in. Images of zebrafish treated with AlCl 3 ( 150 μM, pH 5.8 ) 3... Model group was maintained in the medium with 0.2 % DMSO with the human.! Andre M., Andre M., Akimenko M. A., et al is to look at their behaviour contributors. Https: //doi.org/10.1016/j.bbadis.2010.09.012 Alzheimer disease: amyloidogenesis, the zebrafish amyloid precursor protein-b is required for neuron... Lead to neurodegeneration model group was treated with AlCl 3 ( 150 μM, 5.8... And, in particular, its embryos ) is not a good enough model AD... Of familial Alzheimer 's dementia these models we still lack a detailed understanding of the complete set features! Aspects of this model that require better understanding, we have attempted to establish induced. Allow you to mimic a condition that also occurs in Alzheimer 's.. And stimulation of γ-secretase activity give an overview of how the zebrafish amyloid precursor is. Of existing animal models usually struggle to recapitulate all features of human maladies as. Valuable model for drug testing prior to clinical testing in rodents of the molecular events that lead to and...
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